Description

5-(2,4-Difluorophenyl)Nicotinic Acid is a high-purity, fluorinated nicotinic acid derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its difluorophenyl moiety is essential for modulating biological activity and metabolic stability. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries engaged in the synthesis of novel fluorinated compounds.

Application

• Key synthetic intermediate in the research and development of novel pharmaceutical compounds, particularly kinase inhibitors and other small-molecule therapeutics.
• Building block for the synthesis of advanced agrochemicals, including herbicides and fungicides, where fluorine substitution enhances efficacy.
• Precursor in the manufacture of liquid crystal materials and other specialty electronic chemicals.
• Versatile reagent in academic and industrial R&D for exploring new fluorinated heterocyclic chemistry.
• Intermediate for producing custom fine chemicals and contract manufacturing projects.

Basic Information

Product Name	5-(2,4-Difluorophenyl)Nicotinic Acid
CAS No.	887973-46-8
Molecular Formula	C12H7F2NO2
Molecular Weight	235.19 g/mol
Synonyms	5-(2,4-Difluorophenyl)pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 5-(2,4-difluorophenyl)-; Nicotinic acid, 5-(2,4-difluorophenyl)-; 2,4-Difluoro-5-pyridin-3-ylbenzoic acid (isomer); 5-(2,4-Difluorophenyl)-3-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 5-(2,4-Difluorophenyl)Nicotinic Acid is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment supports applications requiring GMP-grade intermediates and research-standard materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.