Description

5-(2,5-Difluorophenyl)Nicotinic Acid is a high-purity fluorinated nicotinic acid derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its unique difluorophenyl-substituted pyridine structure, which is essential for modulating the physicochemical and pharmacokinetic properties of target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in developing new generations of herbicides and fungicides, where the fluorine atoms enhance biological activity and environmental stability.
• Ligand Synthesis: Serves as a versatile scaffold for constructing complex ligands in catalysis and material science.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes under cGMP conditions.

Basic Information

Product Name	5-(2,5-Difluorophenyl)Nicotinic Acid
CAS No.	887973-41-3
Molecular Formula	C12H7F2NO2
Molecular Weight	235.19 g/mol
Synonyms	5-(2,5-Difluorophenyl)pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 5-(2,5-difluorophenyl)-; Nicotinic acid, 5-(2,5-difluorophenyl)-; 2,5-Difluoro-5'-pyridinyl-3'-carboxylic acid; 5-(2,5-Difluorophenyl)-3-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 5-(2,5-Difluorophenyl)Nicotinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and commercial synthesis. Certificates of Analysis (COA) with detailed chromatographic data (HPLC) are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.