Description

Methyl 3-(3-Bromophenyl)-2-(tert-Butoxycarbonylamino)-2-Methylpropanoate CAS NO 887969-56-4 is a high-purity, non-natural amino acid derivative featuring a brominated aromatic ring and a Boc-protected amine group. This compound is a critical chiral building block for the synthesis of complex pharmaceutical intermediates and active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel therapeutic agents and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel small-molecule drugs, particularly in oncology and CNS therapeutic areas.
• Peptidomimetics Synthesis: Serves as a constrained, non-proteinogenic amino acid analog for constructing peptide-like molecules with enhanced metabolic stability.
• Agrochemical Research: Used as a precursor in the development of new-generation herbicides and plant growth regulators.
• Ligand and Catalyst Development: Employed in the creation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Acts as a building block for fluorescent tags or affinity probes used in biochemical and cellular studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and advanced intermediates under cGMP conditions.

Basic Information

Product Name	Methyl 3-(3-Bromophenyl)-2-(tert-Butoxycarbonylamino)-2-Methylpropanoate
CAS No.	887969-56-4
Molecular Formula	C16H22BrNO4
Molecular Weight	372.26 g/mol
Synonyms	Boc-3-Br-β-methylphenylalanine methyl ester; Methyl (2R/S)-3-(3-bromophenyl)-2-[(tert-butoxycarbonyl)amino]-2-methylpropanoate; 2-Methyl-2-[(tert-butoxycarbonyl)amino]-3-(3-bromophenyl)propanoic acid methyl ester; 3-(3-Bromophenyl)-2-[(tert-butoxycarbonyl)amino]-2-methylpropionic acid methyl ester; Boc-3-(3-bromophenyl)-2-methylalanine methyl ester; N-Boc-3-(3-bromophenyl)-2-methylalanine methyl ester; (RS)-Methyl 3-(3-bromophenyl)-2-(tert-butoxycarbonylamino)-2-methylpropanoate
EINECS	Contact for details

Quality Control

Our Methyl 3-(3-Bromophenyl)-2-(tert-Butoxycarbonylamino)-2-Methylpropanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (or as specified)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.