Description

5-(Chloromethyl)-2-Methoxy-3-(Trifluoromethyl)-Pyridine is a high-value, multi-functional heterocyclic building block characterized by its reactive chloromethyl group and trifluoromethyl substituent. This compound is essential for the synthesis of complex molecules, where it introduces key structural motifs that can significantly alter biological activity and physicochemical properties. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for developing new active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used to construct advanced intermediates for next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the pyridine and trifluoromethyl groups.
• Ligand and Catalyst Development: Serves as a versatile scaffold for creating specialized ligands in transition metal catalysis and organocatalysis for asymmetric synthesis.
• Material Science Research: Employed in the development of functionalized polymers and organic electronic materials due to its aromatic core and potential for further modification.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and scale-up campaigns in fine chemical production.

Basic Information

Product Name	5-(Chloromethyl)-2-Methoxy-3-(Trifluoromethyl)-Pyridine
CAS No.	887707-33-7
Molecular Formula	C8H7ClF3NO
Molecular Weight	225.60 g/mol
Synonyms	2-Methoxy-3-(trifluoromethyl)-5-(chloromethyl)pyridine; 3-(Trifluoromethyl)-2-methoxy-5-pyridinemethanol, chloromethyl ether; 5-(Chloromethyl)-2-methoxy-3-trifluoromethylpyridine; 2-Methoxy-3-trifluoromethyl-5-chloromethylpyridine; 5-Chloromethyl-2-methoxy-3-trifluoromethylpyridine
EINECS	Contact for details

Quality Control

Every batch of 5-(Chloromethyl)-2-Methoxy-3-(Trifluoromethyl)-Pyridine is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.