Description

6-Methoxy-5-(Trifluoromethyl)-3-Pyridinecarbonitrile is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic combination of a methoxy group, a trifluoromethyl group, and a nitrile functionality on a pyridine scaffold, enabling precise molecular modifications. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a building block for functionalized ligands, metal-organic frameworks (MOFs), and specialty polymers requiring specific electronic properties.
• Chemical Biology Probe Development: Employed in the synthesis of labeled compounds and molecular probes for biochemical and diagnostic research applications.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global R&D projects.

Basic Information

Product Name	6-Methoxy-5-(Trifluoromethyl)-3-Pyridinecarbonitrile
CAS No.	887707-29-1
Molecular Formula	C8H5F3N2O
Molecular Weight	202.13 g/mol
Synonyms	3-Cyano-6-methoxy-5-(trifluoromethyl)pyridine; 5-(Trifluoromethyl)-6-methoxynicotinonitrile; 6-Methoxy-5-trifluoromethylpyridine-3-carbonitrile; 6-Methoxy-5-(trifluoromethyl)nicotinonitrile; 6-Methoxy-5-(trifluoromethyl)-3-cyanopyridine; 3-Pyridinecarbonitrile, 6-methoxy-5-(trifluoromethyl)-; 887707-29-1
EINECS	Contact for details

Quality Control

Our 6-Methoxy-5-(Trifluoromethyl)-3-Pyridinecarbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.