Description

5-Iodo-2-Methoxy-3-(Trifluoromethyl)-Pyridinone is a high-value, multi-functional heterocyclic building block featuring iodine, methoxy, and trifluoromethyl substituents. This compound is critical for advanced research and development, enabling the synthesis of complex molecules with tailored electronic and steric properties. It is primarily sought after by pharmaceutical, agrochemical, and advanced materials scientists for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for sophisticated ligands in transition metal catalysis, facilitating challenging cross-coupling and functionalization reactions.
• Material Science: Employed in the creation of organic electronic materials, such as OLEDs and semiconductors, due to its electron-deficient pyridinone core and halogen substituent.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and probe development, leveraging the reactivity of the iodine atom for further functionalization.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs serving the global life sciences industry.

Basic Information

Item	Details
Product Name	5-Iodo-2-Methoxy-3-(Trifluoromethyl)-Pyridinone
CAS No.	887707-27-9
Molecular Formula	C7H5F3INO2
Molecular Weight	318.02 g/mol
Synonyms	5-Iodo-2-methoxy-3-(trifluoromethyl)pyridin-1(2H)-one; 3-(Trifluoromethyl)-5-iodo-2-methoxypyridin-4(1H)-one; 5-Iodo-2-methoxy-3-trifluoromethylpyridinone; 887707-27-9; 5-Iodo-2-methoxy-3-(trifluoromethyl)-1,2-dihydropyridin-4-one; Pyridinone, 5-iodo-2-methoxy-3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 5-Iodo-2-Methoxy-3-(Trifluoromethyl)-Pyridinone is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay (by HPLC), related substances, residual solvents, and heavy metals. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.