Description

1-(3-Amino-Phenyl)-Azetidine-3-Carboxylic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a unique azetidine ring structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel small-molecule therapeutics. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for constructing complex molecular architectures with potential biological activity.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its constrained azetidine scaffold and functional handles.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degradation therapeutics.
• Chemical Biology Probes: Utilized to create tool compounds for investigating biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of APIs (Active Pharmaceutical Ingredients) under cGMP conditions.
• Academic Research: Employed in university and institutional labs for pioneering synthetic methodology and exploring new chemical space.

Basic Information

Product Name	1-(3-Amino-Phenyl)-Azetidine-3-Carboxylic Acid Methyl Ester
CAS No.	887595-89-3
Molecular Formula	C11H14N2O2
Molecular Weight	206.24 g/mol
Synonyms	Methyl 1-(3-aminophenyl)azetidine-3-carboxylate; 3-Azetidinecarboxylic acid, 1-(3-aminophenyl)-, methyl ester; 1-(3-Aminophenyl)azetidine-3-carboxylic acid methyl ester; Methyl 1-(3-aminobenzene)azetidine-3-carboxylate; 1-(m-Aminophenyl)azetidine-3-carboxylic acid methyl ester; Azetidine-3-carboxylic acid, 1-(3-aminophenyl)-, methyl ester; 887595-89-3
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is analyzed using advanced techniques including HPLC, GC, and NMR to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) with detailed chromatographic data are available upon request. We support development from research to commercial scale with consistent quality and full traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive (store away from light). Keep container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.