Description

3-(5-Bromo-Pyridin-3-Yl)-3-Oxo-Propionitrile is a high-purity, versatile chemical intermediate featuring a brominated pyridine core and a reactive cyano-ketone functional group. This compound is valued for its role as a key building block in the synthesis of complex heterocyclic molecules and active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for advanced organic synthesis and drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging its halogenated heterocyclic structure.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of organic electronic materials and specialty polymers.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and scale-up production for clients in the fine chemical sector.

Basic Information

Product Name	3-(5-Bromo-Pyridin-3-Yl)-3-Oxo-Propionitrile
CAS No.	887594-04-9
Molecular Formula	C8H5BrN2O
Molecular Weight	225.04 g/mol
Synonyms	3-(5-Bromopyridin-3-yl)-3-oxopropanenitrile; 3-Oxo-3-(5-bromopyridin-3-yl)propanenitrile; 5-Bromo-3-pyridyl β-ketopropionitrile; 3-(5-Bromo-3-pyridinyl)-3-oxopropanenitrile; 5-Bromo-3-pyridyl cyanomethyl ketone; 3-(5-Bromopyridin-3-yl)-3-oxo-propiononitrile; (5-Bromo-3-pyridyl) 2-cyanoethyl ketone
EINECS	Contact for details

Quality Control

Our production of 3-(5-Bromo-Pyridin-3-Yl)-3-Oxo-Propionitrile adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory filings for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere to prevent degradation. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.