Description

3-(3-Cyano-Benzenesulfonyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a benzenesulfonyl-piperidine scaffold. This compound is valued for its role as a key building block in the synthesis of complex bioactive molecules, particularly in medicinal chemistry research and development. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel compounds with potential therapeutic applications.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of potential drug candidates, especially those targeting enzymes or receptors where the sulfonyl-piperidine moiety is pharmacologically relevant.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and improve the pharmacokinetic properties of new chemical entities.
• Protease Inhibitor Development: Serves as a core scaffold or precursor in the design and synthesis of protease inhibitors, given the common use of sulfonamide groups in such inhibitors.
• Chemical Biology Probes: Utilized to create specialized molecular probes for studying biological pathways and target engagement within cellular systems.
• Agrochemical Synthesis: Acts as an intermediate in the development of new active ingredients for crop protection products.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	3-(3-Cyano-Benzenesulfonyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	887589-95-9
Molecular Formula	C17H22N2O4S
Molecular Weight	350.44 g/mol
Synonyms	1-Boc-3-[(3-cyanophenyl)sulfonyl]piperidine; tert-Butyl 3-[(3-cyanophenyl)sulfonyl]piperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-[(3-cyanophenyl)sulfonyl]piperidine; 3-(3-Cyanobenzenesulfonyl)piperidine-1-carboxylic Acid tert-Butyl Ester; N-Boc-3-(3-cyanobenzenesulfonyl)piperidine; Piperidine-1-carboxylic acid, 3-[(3-cyanophenyl)sulfonyl]-, 1,1-dimethylethyl ester; 887589-95-9
EINECS	Contact for details

Quality Control

Our 3-(3-Cyano-Benzenesulfonyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications from research to pre-clinical development, with the capability to supply material meeting higher purity standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.