Description

1-Boc-3-(3-Trifluoromethyl-Phenylamino)-Piperidine is a high-purity, advanced pharmaceutical intermediate featuring a protected piperidine scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting the central nervous system and other therapeutic areas. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for lead optimization and scale-up activities.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially those with piperidine-based pharmacophores.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead compound optimization for various disease targets.
• Process Chemistry Development: Serves as a critical starting material or intermediate in the development and scale-up of synthetic routes for active pharmaceutical ingredients (APIs).
• Protease Inhibitor Synthesis: The structural motif is relevant in the development of protease inhibitors and other enzyme-targeted therapies.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	1-Boc-3-(3-Trifluoromethyl-Phenylamino)-Piperidine
CAS No.	887585-04-8
Molecular Formula	C17H23F3N2O2
Molecular Weight	344.37 g/mol
Synonyms	1-Boc-3-[(3-(trifluoromethyl)phenyl)amino]piperidine; tert-Butyl 3-[(3-(trifluoromethyl)phenyl)amino]piperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-[(3-(trifluoromethyl)phenyl)amino]piperidine; 3-[(3-Trifluoromethylphenyl)amino]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; N-Boc-3-(3-Trifluoromethyl-anilino)piperidine; 1-Boc-3-(3-Trifluoromethyl-anilino)piperidine; Piperidine, 3-[[3-(trifluoromethyl)phenyl]amino]-, 1-(1,1-dimethylethyl) 1-carbamate
EINECS	Contact for details

Quality Control

Every batch of 1-Boc-3-(3-Trifluoromethyl-Phenylamino)-Piperidine is produced under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality management system supports the delivery of material suitable for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation (by NMR and IR), and impurity profile is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.