Description

1-Boc-3-(2-Fluoro-Benzylamino)-Piperidine is a high-purity, advanced pharmaceutical intermediate featuring a protected piperidine scaffold with a fluorinated benzylamine substituent. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel drug candidates with enhanced metabolic stability and binding affinity. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in the areas of central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical development.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to explore new chemical entities.
• Protease Inhibitor Development: Serves as a core scaffold for the design and synthesis of protease enzyme inhibitors.
• GPCR-Targeted Drug Discovery: Employed in the development of ligands targeting G-protein coupled receptors, relevant to neurological and psychiatric disorders.
• Kinase Inhibitor Synthesis: A versatile precursor in the creation of kinase inhibitor libraries for oncology research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	1-Boc-3-(2-Fluoro-Benzylamino)-Piperidine
CAS No.	887584-83-0
Molecular Formula	C17H25FN2O2
Molecular Weight	308.40 g/mol
Synonyms	1-Boc-3-[(2-Fluorophenyl)methylamino]piperidine; tert-Butyl 3-[(2-fluorobenzyl)amino]piperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-[(2-fluorobenzyl)amino]piperidine; 3-[(2-Fluorobenzyl)amino]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; N-(2-Fluorobenzyl)-1-N-Boc-piperidin-3-amine; 1-Boc-3-(2-Fluorobenzylamino)piperidine; Piperidine, 3-[(2-fluorophenyl)methyl]amino]-1-[(1,1-dimethylethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our 1-Boc-3-(2-Fluoro-Benzylamino)-Piperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with the standards expected for pharmaceutical R&D and cGMP intermediate supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.