Description

4-Bromo-2-Trifluoromethylpyridine is a high-value halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and trifluoromethyl substituents, provides versatile reactivity for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science: Used in the development of specialty polymers, liquid crystals, and electronic materials where fluorine-containing aromatics impart desired stability and properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing novel nitrogen-containing ligands for metal catalysis.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D for exploring new synthetic methodologies and creating compound libraries.

Basic Information

Product Name	4-Bromo-2-Trifluoromethylpyridine
CAS No.	887583-90-6
Molecular Formula	C6H3BrF3N
Molecular Weight	225.99 g/mol
Synonyms	2-Trifluoromethyl-4-bromopyridine; 4-Bromo-2-(trifluoromethyl)pyridine; Pyridine, 4-bromo-2-(trifluoromethyl)-; 4-Bromo-α,α,α-trifluoro-2-picoline
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Trifluoromethylpyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistent quality. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for use in regulated applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.