Description

1-Boc-4-[(3-Fluoro-Phenylamino)-Methyl]-Piperidine is a high-purity, advanced pharmaceutical intermediate featuring a protected piperidine scaffold with a fluorinated aniline moiety. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel drug candidates with enhanced metabolic stability and binding affinity. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the creation of targeted small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize the biological activity of new chemical entities.
• Process Chemistry & Scale-Up: Serves as a critical intermediate in the development and optimization of scalable synthetic routes for drug candidates under Good Manufacturing Practice (GMP) conditions.
• Protease Inhibitor Development: The Boc-protected piperidine structure is valuable for constructing inhibitors of various proteases and kinases.
• Library Synthesis for High-Throughput Screening: Employed in the generation of diverse compound libraries for biological screening against novel targets.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis organizations (CSOs) and CDMOs producing bespoke intermediates for client projects.

Basic Information

Item	Detail
Product Name	1-Boc-4-[(3-Fluoro-Phenylamino)-Methyl]-Piperidine
CAS No.	887582-27-6
Molecular Formula	C17H25FN2O2
Molecular Weight	308.40 g/mol
Synonyms	tert-Butyl 4-[(3-fluoroanilino)methyl]piperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-[(3-fluorophenylamino)methyl]piperidine; 4-[(3-Fluoroanilino)methyl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; N-(3-Fluorophenyl)-N-(piperidin-4-ylmethyl)carbamic acid tert-butyl ester; 1-Boc-4-(3-fluoroanilinomethyl)piperidine; 1-Boc-4-(3-FAPM)-Piperidine; Boc-4-(3-Fluoro-Phenylamino-Methyl)-Piperidine.
EINECS	Contact for details

Quality Control

Our 1-Boc-4-[(3-Fluoro-Phenylamino)-Methyl]-Piperidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, confirming compliance with client specifications and industry best practices for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.