Description

tert-Butyl 2-bromoisonicotinate is a high-purity, versatile brominated pyridine derivative serving as a critical building block in advanced organic synthesis. Its value lies in the strategic positioning of the bromine atom and the tert-butyl ester group, which facilitate efficient cross-coupling reactions and subsequent functional group transformations. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it is used to construct complex molecular architectures for active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing functionalized pyridine cores.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and insecticides that require halogenated heterocyclic structures.
• Material Science Research: Used in the development of organic electronic materials, ligands for catalysis, and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: Serves as a reliable substrate for Suzuki-Miyaura, Stille, and Negishi couplings to introduce the isonicotinate moiety into more complex systems.
• Chemical Biology: Utilized in the synthesis of molecular probes and tagged compounds for biochemical research and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and development of scalable synthetic routes.

Basic Information

Product Name	tert-Butyl 2-Bromoisonicotinate
CAS No.	887579-30-8
Molecular Formula	C10H12BrNO2
Molecular Weight	258.11 g/mol
Synonyms	2-Bromoisonicotinic acid tert-butyl ester; tert-Butyl 2-bromopyridine-4-carboxylate; 4-Pyridinecarboxylic acid, 2-bromo-, 1,1-dimethylethyl ester; 2-Bromo-4-(tert-butoxycarbonyl)pyridine; 2-Bromopyridine-4-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-bromoisonicotinate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to verify identity, potency, and impurity profiles. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive material from prolonged exposure and to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.