Description

1-Boc-3-(Pyridin-4-Ylamino)-Pyrrolidine is a high-purity, advanced pharmaceutical intermediate featuring a protected amine and a pyridine-substituted pyrrolidine scaffold. This compound is critical for medicinal chemistry research and development, enabling the synthesis of complex molecules with targeted biological activity. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Protease Inhibitor Synthesis: Serves as a precursor in the development of protease inhibitors due to its pyrrolidine core.
• Kinase Inhibitor Development: Employed in the construction of heterocyclic scaffolds for potential kinase inhibitor candidates.
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis services catering to the pharmaceutical and biotech industries.

Basic Information

Product Name	1-Boc-3-(Pyridin-4-Ylamino)-Pyrrolidine
CAS No.	887578-87-2
Molecular Formula	C14H21N3O2
Molecular Weight	263.34 g/mol
Synonyms	tert-Butyl 3-[(pyridin-4-yl)amino]pyrrolidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-[(4-pyridinyl)amino]pyrrolidine; 3-(Pyridin-4-ylamino)pyrrolidine-1-carboxylic acid tert-butyl ester; 1-Boc-3-(4-pyridylamino)pyrrolidine; N-Boc-3-amino-4-(pyridin-4-ylamino)pyrrolidine (common misnomer); BOC-3-(4-Pyridylamino)pyrrolidine; Pyrrolidine, 3-[(4-pyridinyl)amino]-, 1-(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our 1-Boc-3-(Pyridin-4-Ylamino)-Pyrrolidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.