Description

Methyl 1,4-Dihydro-4-(2'-Trifluoromethyl)Phenyl-Pyridine-3-Carboxylate-5-Ethyl Carboxamide is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyridine-carboxamide structure and trifluoromethylphenyl moiety. This compound is critical for research and development in medicinal chemistry, offering a versatile building block for creating novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex molecules targeting central nervous system and cardiovascular applications. The compound's specific structure makes it a valuable synthon for lead optimization and process development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular research.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Process Chemistry Development: Serves as a critical starting material or intermediate for scaling up API synthesis under Good Manufacturing Practice (GMP) conditions.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development of proprietary compounds for clients.
• Academic Research: Utilized in university and institutional labs for studying heterocyclic chemistry and fluorinated compound reactivity.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in API production.

Basic Information

Item	Detail
Product Name	Methyl 1,4-Dihydro-4-(2'-Trifluoromethyl)Phenyl-Pyridine-3-Carboxylate-5-Ethyl Carboxamide
CAS No.	887407-06-9
Molecular Formula	C17H17F3N2O3
Molecular Weight	354.33 g/mol
Synonyms	5-Ethylcarbamoyl-4-(2-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3-carboxylic acid methyl ester; Methyl 5-(ethylcarbamoyl)-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate; 1,4-DHP derivative with 2'-trifluoromethylphenyl and 5-ethylcarboxamide substituents; 4-(2-Trifluoromethylphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl ester 5-ethylamide; CAS 887407-06-9; Ethyl 4-(2-trifluoromethylphenyl)-1,4-dihydropyridine-3,5-dicarboxylate 5-amide derivative; Trifluoromethylphenyl DHP carboxamide ester
EINECS	Contact for details

Quality Control

Our Methyl 1,4-Dihydro-4-(2'-Trifluoromethyl)Phenyl-Pyridine-3-Carboxylate-5-Ethyl Carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing batch-specific results are provided with every shipment. We adhere to relevant guidelines for the handling of advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Due to its sensitivity to light and potential reactivity with strong bases and fluorides, appropriate chemical storage segregation practices should be followed.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 1.0%; Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.