Description

2,2-Difluoro-3-Hydroxy-(3-Pyridyl)Propionyl Amide is a high-value, organofluorine building block featuring a pyridine ring and an amide functional group. This compound is critical for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where its unique difluorinated hydroxypropionyl amide scaffold imparts desirable biological activity and metabolic stability. It is primarily utilized by research and development chemists and process scale-up teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to innovate new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug candidates.
• Agrochemical Synthesis: Serves as a precursor for developing new generation herbicides and fungicides with enhanced efficacy and environmental profile.
• Chemical Biology Probe: Used in medicinal chemistry for structure-activity relationship (SAR) studies and as a molecular scaffold in probe design.
• Organic Synthesis Building Block: Employed in complex organic synthesis, including cross-coupling reactions and amide bond formations, to introduce fluorinated motifs.
• Material Science Research: Potential monomer or additive in the development of specialty polymers with specific optical or electronic properties.

Basic Information

Product Name	2,2-Difluoro-3-Hydroxy-(3-Pyridyl)Propionyl Amide
CAS No.	887354-60-1
Molecular Formula	C9H8F2N2O2
Molecular Weight	214.17 g/mol
Synonyms	2,2-Difluoro-3-hydroxy-3-(pyridin-3-yl)propanamide; 3-Pyridinepropanamide, 2,2-difluoro-3-hydroxy-; 2,2-Difluoro-3-hydroxy-3-(3-pyridinyl)propanamide; 2,2-Difluoro-3-(pyridin-3-yl)-3-hydroxypropanamide; 3-(2,2-Difluoro-3-hydroxypropanoyl)pyridine; (RS)-2,2-Difluoro-3-hydroxy-3-(pyridin-3-yl)propanamide
EINECS	Contact for details

Quality Control

Our 2,2-Difluoro-3-Hydroxy-(3-Pyridyl)Propionyl Amide is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP standards for advanced intermediate production upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.