Description

2,2-Difluoro-3-Hydroxy-(3-Pyridyl)Propionic Acid is a high-value, fluorinated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both difluoro and hydroxypyridyl moieties, makes it an essential intermediate for creating novel compounds with enhanced biological activity and material properties. This product is primarily targeted at research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop next-generation active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new active pharmaceutical ingredients (APIs), particularly in oncology, antiviral, and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms can improve metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Utilized to create fluorinated probes and tags for studying enzyme mechanisms and protein interactions.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	2,2-Difluoro-3-Hydroxy-(3-Pyridyl)Propionic Acid
CAS No.	887354-54-3
Molecular Formula	C8H7F2NO3
Molecular Weight	203.14 g/mol
Synonyms	3-Pyridinepropanoic acid, 2,2-difluoro-3-hydroxy-; 2,2-Difluoro-3-hydroxy-3-(3-pyridinyl)propanoic acid; 3-(3-Pyridyl)-2,2-difluoro-3-hydroxypropionic acid; 887354-54-3; 2,2-Difluoro-3-hydroxy-3-pyridin-3-ylpropionic acid
EINECS	Contact for details

Quality Control

Every batch of 2,2-Difluoro-3-Hydroxy-(3-Pyridyl)Propionic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the exacting standards required for research and commercial synthesis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation and maintain purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.