Description

4-Amino-3-Chloro-5-(Trifluoromethyl)Pyridine is a high-value, multi-functional heterocyclic building block distinguished by its unique trifluoromethyl and chloro substituents. This compound is essential for medicinal chemistry and agrochemical research, where it serves as a critical precursor for synthesizing novel active pharmaceutical ingredients (APIs) and crop protection agents. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors. Its structural features enable the introduction of key pharmacophores, making it indispensable for creating compounds with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of small molecule drugs, particularly kinase inhibitors and other targeted therapies.
• Agrochemical Active Ingredient Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in catalytic processes and metal-organic frameworks (MOFs).
• Material Science Research: Incorporated into the design of advanced organic electronic materials and functional polymers.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis and Contract Manufacturing: Supplied for bespoke synthesis projects requiring a specific, high-purity pyridine derivative.

Basic Information

Product Name	4-Amino-3-Chloro-5-(Trifluoromethyl)Pyridine
CAS No.	887268-37-3
Molecular Formula	C6H4ClF3N2
Molecular Weight	196.56 g/mol
Synonyms	3-Chloro-5-(trifluoromethyl)pyridin-4-amine; 4-Amino-3-chloro-5-trifluoromethylpyridine; 3-Chloro-5-trifluoromethyl-4-pyridinamine; 4-Pyridinamine, 3-chloro-5-(trifluoromethyl)-; 5-(Trifluoromethyl)-3-chloropyridin-4-amine
EINECS	Contact for details

Quality Control

Every batch of 4-Amino-3-Chloro-5-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency meet the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.