Description

o-Methyl Atorvastatin Calcium Salt is a key pharmaceutical intermediate in the synthesis of atorvastatin, the active ingredient in leading cholesterol-lowering medications. This compound is critical for research and development, enabling precise structural modifications and metabolic studies. It is primarily utilized by pharmaceutical manufacturers, R&D laboratories, and fine chemical suppliers focused on cardiovascular drug development and generic API production.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthetic pathway for Atorvastatin API.
• Research & Development: Used in metabolic and pharmacokinetic studies to understand drug behavior.
• Process Chemistry: Serves as a reference standard and starting material for process optimization and scale-up.
• Analytical Standard: Employed as a high-purity standard for HPLC, LC-MS, and other analytical method development.
• Generic Drug Manufacturing: Essential for companies developing bioequivalent versions of cholesterol-lowering drugs.
• Academic Research: Used in universities and institutes for medicinal chemistry and organic synthesis projects.

Basic Information

Product Name	o-Methyl Atorvastatin Calcium Salt
CAS No.	887196-29-4
Molecular Formula	C39H36CaF2N2O6 (or corresponding hydrate/adduct)
Molecular Weight	Contact for details
Synonyms	Atorvastatin o-Methyl Ester Calcium Salt; (3R,5R)-7-[2-(4-Fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic Acid Methyl Ester Calcium Salt; o-Methyl Atorvastatin Ca Salt; Atorvastatin Impurity; Atorvastatin Related Compound; Atorvastatin Methyl Ester Calcium; CAS 887196-29-4
EINECS	Contact for details

Quality Control

Our o-Methyl Atorvastatin Calcium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical intermediates. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.