Description

tert-Butyl 5,8-Diazaspiro[3.5]Nonane-8-Carboxylate is a high-value, protected spirocyclic amine building block used in advanced organic synthesis. This compound is crucial for medicinal chemistry research, providing a rigid, three-dimensional scaffold that is essential for developing novel bioactive molecules. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for constructing complex drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially for neurological and psychiatric disorders.
• Medicinal Chemistry Scaffold: Used to introduce a constrained, spirocyclic amine moiety into lead compounds to optimize potency, selectivity, and pharmacokinetic properties.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker component in the design of bifunctional degrader molecules.
• Chemical Biology Probes: Employed in the creation of tool compounds for target identification and validation in biological pathways.
• Agrochemical Research: Potential intermediate for developing new crop protection agents with novel modes of action.
• Academic Research: Used in universities and research institutes for methodological studies in heterocyclic and spiro compound chemistry.

Basic Information

Product Name	tert-Butyl 5,8-Diazaspiro[3.5]Nonane-8-Carboxylate
CAS No.	886766-31-0
Molecular Formula	C12H22N2O2
Molecular Weight	226.32 g/mol
Synonyms	8-Boc-5,8-diazaspiro[3.5]nonane; tert-Butyl 5,8-diazaspiro[3.5]nonane-8-carboxylate; 5,8-Diazaspiro[3.5]nonane-8-carboxylic acid, 1,1-dimethylethyl ester; 8-(tert-Butoxycarbonyl)-5,8-diazaspiro[3.5]nonane; Boc-5,8-diazaspiro[3.5]nonane; 5,8-Diazaspiro[3.5]nonane, 8-Boc-protected; 1,1-Dimethylethyl 5,8-diazaspiro[3.5]nonane-8-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 5,8-Diazaspiro[3.5]Nonane-8-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with cGMP and ICH Q7 guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.