Description

2-Chloro-4-(Trifluoromethyl)Nicotinamide is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated and trifluoromethylated pyridine structure. This compound is of significant commercial importance for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the agrochemical and pharmaceutical research sectors. It is primarily sought after by R&D chemists and process development scientists working on innovative small molecule therapeutics and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block in the research and development of new drug candidates, especially those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Serves as a critical precursor for the manufacture of modern pesticides and herbicides, leveraging the biological activity of the trifluoromethyl group.
• Chemical Research & Development: Used in academic and industrial laboratories for exploring novel heterocyclic chemistry and structure-activity relationships (SAR).
• Process Chemistry: Employed in scale-up and optimization studies for the commercial production of complex organic molecules.
• Material Science: Potential intermediate in the synthesis of specialty chemicals and functional materials requiring specific fluorinated motifs.

Basic Information

Product Name	2-Chloro-4-(Trifluoromethyl)Nicotinamide
CAS No.	886762-28-3
Molecular Formula	C7H4ClF3N2O
Molecular Weight	224.57 g/mol
Synonyms	2-Chloro-4-(trifluoromethyl)pyridine-3-carboxamide; 3-Pyridinecarboxamide, 2-chloro-4-(trifluoromethyl)-; 2-Chloro-4-trifluoromethylnicotinamide; 2-Chloro-4-(trifluoromethyl)nicotinic acid amide; 886762-28-3; Nicotinamide, 2-chloro-4-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-4-(Trifluoromethyl)Nicotinamide is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including HPLC, NMR, and GC-MS analysis, to ensure compliance with industry standards and customer-specific requirements. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.