Description

5'-Trifluoromethyl-3,4,5,6-Tetrahydro-2 H-[1,2']Bipyridinyl-4-Carboxylic Acid Hydrazide is a high-purity, advanced pharmaceutical intermediate characterized by its unique bipyridinyl scaffold and reactive hydrazide functional group. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel drug candidates targeting a range of therapeutic areas. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to incorporate a trifluoromethylated, nitrogen-rich heterocyclic structure into their molecular designs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates, especially in central nervous system (CNS) and oncology research.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization due to its versatile hydrazide moiety, which can be further derivatized into amides, hydrazones, and heterocycles.
• Agrochemical Research: Serves as a precursor in the development of new herbicides, fungicides, or insecticides leveraging the biological activity of the bipyridinyl core.
• Ligand Synthesis: Potential precursor for creating chelating ligands in catalysis or metal-organic frameworks (MOFs), given its multiple nitrogen donor sites.
• Chemical Biology Probes: Useful for developing molecular probes and biochemical tools to study enzyme inhibition or protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific trifluoromethylated scaffold.

Basic Information

Product Name	5'-Trifluoromethyl-3,4,5,6-Tetrahydro-2 H-[1,2']Bipyridinyl-4-Carboxylic Acid Hydrazide
CAS No.	886496-29-3
Molecular Formula	C12H15F3N4O
Molecular Weight	288.27 g/mol
Synonyms	4-Hydrazinylcarbonyl-5'-(trifluoromethyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl; 5'-(Trifluoromethyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-carboxylic acid hydrazide; 4-Carbohydrazide-5'-(trifluoromethyl)-1,2,3,6-tetrahydropyrido[2,1-c][1,4]oxazine; 5'-Trifluoromethyl-1,2,3,6-tetrahydropyrido[2,1-c][1,4]oxazine-4-carbohydrazide; (5'-(Trifluoromethyl)-3,4,5,6-tetrahydro-2H-[1,2'-bipyridin]-4-yl)methanohydrazide; TFMPO-CH
EINECS	Contact for details

Quality Control

Our 5'-Trifluoromethyl-3,4,5,6-Tetrahydro-2 H-[1,2']Bipyridinyl-4-Carboxylic Acid Hydrazide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support compliance with REACH and other global regulatory frameworks as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled and stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.