Description

6-Bromo-2-(trifluoromethyl)oxazolo[5,4-b]pyridine is a high-value, multi-functional heterocyclic building block featuring a fused oxazolopyridine core. This compound is specifically engineered to serve as a critical intermediate in advanced organic synthesis, offering unique reactivity due to the strategic placement of bromo and trifluoromethyl substituents. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the construction of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging the bioactivity of the fluorinated heterocycle.
• Material Science Research: Serves as a precursor for organic electronic materials, such as ligands for OLEDs or charge-transport molecules.
• Chemical Biology Probes: Employed in the synthesis of molecular probes and tags for studying biological systems and mechanisms.
• Cross-Coupling Reactions: The bromine atom provides an excellent handle for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira).
• Fluorine Chemistry: The stable trifluoromethyl group is valuable for modulating lipophilicity, metabolic stability, and binding affinity in lead optimization.

Basic Information

Product Name	6-Bromo-2-(trifluoromethyl)oxazolo[5,4-b]pyridine
CAS No.	886373-24-6
Molecular Formula	C7H2BrF3N2O
Molecular Weight	266.99 g/mol
Synonyms	6-Bromo-2-(trifluoromethyl)[1,3]oxazolo[5,4-b]pyridine; 2-(Trifluoromethyl)-6-bromooxazolo[5,4-b]pyridine; 6-Bromo-2-trifluoromethyl-oxazolo[5,4-b]pyridine; Oxazolo[5,4-b]pyridine, 6-bromo-2-(trifluoromethyl)-; 886373-24-6
EINECS	Contact for details

Quality Control

Our 6-Bromo-2-(trifluoromethyl)oxazolo[5,4-b]pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.