Description

2-Pyridinecarboxylic Acid, 4-Bromo-6-Methyl-, Methyl Ester is a high-purity, functionalized pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique bromo-methyl substitution pattern makes it a versatile intermediate for constructing complex molecular architectures, particularly in pharmaceutical and agrochemical research. This compound is essential for medicinal chemists and process development scientists working on novel active ingredients, where precise structural control is paramount for achieving desired biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), especially in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Research: Used in the synthesis of advanced crop protection agents, including herbicides and fungicides, leveraging its halogenated pyridine core.
• Ligand Synthesis: Serves as a precursor for creating specialized ligands in catalysis and coordination chemistry.
• Material Science: Building block for functionalized polymers and advanced organic electronic materials.
• Chemical Biology: Employed in the synthesis of molecular probes and tool compounds for studying biological pathways.
• Custom Synthesis & Scale-Up: A starting material for contract research and manufacturing organizations (CROs/CMOs) engaged in custom synthesis projects from milligram to kilogram scale.

Basic Information

Product Name	2-Pyridinecarboxylic Acid, 4-Bromo-6-Methyl-, Methyl Ester
CAS No.	886372-49-2
Molecular Formula	C8H8BrNO2
Molecular Weight	230.06 g/mol
Synonyms	4-Bromo-6-methylpicolinic acid methyl ester; Methyl 4-bromo-6-methylpicolinate; 4-Bromo-6-methyl-2-pyridinecarboxylic acid methyl ester; 2-Pyridinecarboxylic acid, 4-bromo-6-methyl-, methyl ester; Methyl 4-bromo-6-methylpyridine-2-carboxylate; 4-Bromo-6-methyl-pyridine-2-carboxylic acid methyl ester; Picolinic acid, 4-bromo-6-methyl-, methyl ester
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for this advanced intermediate, ensuring batch-to-batch consistency critical for research and development. Our standard grade typically meets a purity specification of ≥97% (by HPLC), with options for higher purity grades (≥98% and ≥99%) available to support demanding applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. Our quality management system is designed to support cGMP-compliant workflows for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Related Substances (HPLC)	Total impurities ≤3.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.