Description

4-(2,2,2-Trifluoro-Ethoxy)-Pyridine-2-Carboxylic Acid is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring a trifluoroethoxy side chain, is essential for modulating the physicochemical properties of target molecules, particularly enhancing metabolic stability and lipophilicity. This compound is primarily sought after by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in kinase inhibitor and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, where the fluorine moiety contributes to improved efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for sophisticated ligands in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic electronic materials.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	4-(2,2,2-Trifluoro-Ethoxy)-Pyridine-2-Carboxylic Acid
CAS No.	886372-43-6
Molecular Formula	C8H6F3NO3
Molecular Weight	221.13 g/mol
Synonyms	4-(2,2,2-Trifluoroethoxy)picolinic acid; 2-Pyridinecarboxylic acid, 4-(2,2,2-trifluoroethoxy)-; 4-(Trifluoroethoxy)-2-pyridinecarboxylic acid; 4-(TFEO)-Picolinic Acid; 886372-43-6; 4-(2,2,2-Trifluoroethoxy)pyridine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 4-(2,2,2-Trifluoro-Ethoxy)-Pyridine-2-Carboxylic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We operate under a quality system designed to meet the rigorous demands of GMP and ISO standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.