Description

1-(2-Bromo-Pyridin-3-Yl)-2,2,2-Trifluoro-Ethanone is a high-purity, advanced pharmaceutical intermediate characterized by its brominated pyridine and trifluoroacetyl functional groups. This compound is essential for facilitating complex molecular transformations, particularly in the synthesis of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel compounds and fine-tuning molecular properties.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, particularly those requiring a bromopyridine moiety for further functionalization via cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoroacetyl group can impart desirable biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for developing novel organic electronic materials, ligands for catalysts, and specialty polymers.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form new carbon-carbon bonds.
• Fluorinated Compound Development: The trifluoroacetyl group is a valuable source of fluorine, which is crucial for modifying the lipophilicity, bioavailability, and stability of target molecules.
• Chemical Research & Development: Employed in academic and industrial R&D labs for method development, library synthesis, and exploring new chemical spaces.

Basic Information

Product Name	1-(2-Bromo-Pyridin-3-Yl)-2,2,2-Trifluoro-Ethanone
CAS No.	886371-13-7
Molecular Formula	C7H3BrF3NO
Molecular Weight	253.00 g/mol
Synonyms	2-Bromo-3-(trifluoroacetyl)pyridine; 2-Bromo-3-pyridyl trifluoromethyl ketone; 1-(2-Bromopyridin-3-yl)-2,2,2-trifluoroethanone; 3-(Trifluoroacetyl)-2-bromopyridine; 2-Bromo-3-trifluoroacetylpyridine; 2-Bromo-α,α,α-trifluoro-3-pyridyl methyl ketone; 1-(2-Bromo-3-pyridinyl)-2,2,2-trifluoroethanone
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is analyzed using advanced techniques including HPLC, GC, NMR, and mass spectrometry to confirm identity, purity, and the absence of critical impurities. We adhere to strict in-house specifications and can provide supporting documentation, including comprehensive Certificates of Analysis (COA), upon request to meet your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.