Description

Methyl 5-Bromo-2-Chloroisonicotinate is a high-purity halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a functionalized scaffold for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This intermediate is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality raw materials for their synthetic routes.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in catalytic systems and material science.
• Chemical Research: Employed in academic and industrial R&D for exploring new heterocyclic chemistry and reaction methodologies.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	Methyl 5-Bromo-2-Chloroisonicotinate
CAS No.	886365-28-2
Molecular Formula	C7H5BrClNO2
Molecular Weight	250.48 g/mol
Synonyms	Methyl 5-bromo-2-chloropyridine-4-carboxylate; 5-Bromo-2-chloroisonicotinic acid methyl ester; 2-Chloro-5-bromo-4-pyridinecarboxylic acid methyl ester; 4-Pyridinecarboxylic acid, 5-bromo-2-chloro-, methyl ester; Methyl 2-chloro-5-bromoisonicotinate
EINECS	Contact for details

Quality Control

Our Methyl 5-Bromo-2-Chloroisonicotinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles where applicable, ensuring a reliable supply for demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.