Description

1-[Carboxy-(4-Methylsulfanyl-Phenyl)-Methyl]-Piperidine-3-Carboxylic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate with a complex molecular structure designed for sophisticated synthesis pathways. This compound matters for its role as a critical building block in the research and development of new active pharmaceutical ingredients (APIs), particularly those targeting neurological and metabolic disorders. Pharmaceutical R&D teams, contract research organizations (CROs), and fine chemical manufacturers need this ester for its specific reactivity and potential to form the core scaffold of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of novel drug candidates, especially in central nervous system (CNS) and metabolic disease research.
• Active Pharmaceutical Ingredient (API) Development: Used as a structural motif in the design and development of new APIs, leveraging the piperidine and carboxylic ester functionalities.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to improve drug potency and selectivity.
• Process Chemistry & Scale-Up: Acts as a critical material for process development and optimization before commercial-scale API manufacturing.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs engaged in custom synthesis and development services for the global pharmaceutical industry.
• Bioconjugation & Prodrug Synthesis: The carboxylic acid and ester groups provide handles for bioconjugation or the creation of prodrug formulations to enhance bioavailability.

Basic Information

Product Name	1-[Carboxy-(4-Methylsulfanyl-Phenyl)-Methyl]-Piperidine-3-Carboxylic Acid Ethyl Ester
CAS No.	886363-60-6
Molecular Formula	C18H23NO4S
Molecular Weight	349.44 g/mol
Synonyms	Ethyl 1-[(4-(Methylthio)phenyl)(carboxy)methyl]-3-piperidinecarboxylate; 1-[(4-Methylsulfanylphenyl)(carboxy)methyl]piperidine-3-carboxylic Acid Ethyl Ester; 3-Piperidinecarboxylic acid, 1-[(4-(methylthio)phenyl)carbonyl]methyl]-, ethyl ester; 886363-60-6; UNII-7J4WYK1Y0I; 1-[(4-Methylmercaptophenyl)(carboxy)methyl]piperidine-3-carboxylic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our 1-[Carboxy-(4-Methylsulfanyl-Phenyl)-Methyl]-Piperidine-3-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.