Description

[4-(tert-Butyl-Dimethyl-Silanyloxymethyl)Phenyl]-Acetic Acid is a high-value, organosilicon-protected synthetic intermediate crucial for advanced organic synthesis. This compound matters because it provides a strategically protected carboxylic acid functionality, enabling precise, multi-step reactions in sensitive chemical environments without unwanted side reactions. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures, particularly in peptide mimetics and active pharmaceutical ingredient (API) development.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially those requiring protected functional groups for selective coupling reactions.
• Peptidomimetic Research: Used to introduce protected phenylacetic acid moieties into peptide backbones to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Intermediate in the production of advanced herbicides and fungicides where the tert-butyldimethylsilyl (TBDMS) group offers crucial reaction control.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science: Employed in the synthesis of functionalized monomers for specialty polymers and advanced organic electronic materials.
• Custom Chemical Synthesis: A versatile reagent for contract research organizations (CROs) and CDMOs performing bespoke synthesis for clients.

Basic Information

Product Name	[4-(tert-Butyl-Dimethyl-Silanyloxymethyl)Phenyl]-Acetic Acid
CAS No.	886363-54-8
Molecular Formula	C15H24O3Si
Molecular Weight	280.44 g/mol
Synonyms	2-[4-[[(1,1-Dimethylethyl)dimethylsilyl]oxymethyl]phenyl]acetic Acid; 4-[(tert-Butyldimethylsilyloxy)methyl]phenylacetic Acid; TBDMS-Protected 4-Hydroxymethylphenylacetic Acid; [4-(TBDMS-oxymethyl)phenyl]acetic Acid; 4-(tert-Butyldimethylsiloxymethyl)benzeneacetic Acid; (4-((tert-Butyldimethylsilyloxy)methyl)phenyl)acetic Acid; 886363-54-8; Acetic acid, 2-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxymethyl]phenyl]-
EINECS	Contact for details

Quality Control

Every batch of [4-(tert-Butyl-Dimethyl-Silanyloxymethyl)Phenyl]-Acetic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistency suitable for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. The container must be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.