Description

8-n-Boc-5,6,7,8-Tetrahydro-1,8-Naphthyridin-2-Propoinic Acid is a high-purity, advanced pharmaceutical intermediate featuring a protected amine group (Boc) and a carboxylic acid functional handle. This compound is critical for medicinal chemistry research and development, enabling the synthesis of complex molecules with precise structural control. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), particularly within the fields of oncology and central nervous system (CNS) therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel drug candidates, especially naphthyridine-based compounds.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its versatile reactive sites.
• Protease Inhibitor Development: Serves as a core scaffold or precursor in the design and synthesis of protease inhibitors.
• Kinase Inhibitor Synthesis: Employed in the construction of potential kinase inhibitor libraries for high-throughput screening.
• Peptidomimetics: The carboxylic acid moiety allows for coupling reactions to create peptide-like structures with enhanced stability.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	8-n-Boc-5,6,7,8-Tetrahydro-1,8-Naphthyridin-2-Propoinic Acid
CAS No.	886362-45-4
Molecular Formula	C17H24N2O4
Molecular Weight	320.39 g/mol
Synonyms	tert-Butyl 2-(2-carboxyethyl)-5,6,7,8-tetrahydro-1,8-naphthyridine-8(7H)-carboxylate; 8-(tert-Butoxycarbonyl)-5,6,7,8-tetrahydro-1,8-naphthyridine-2-propanoic Acid; 8-Boc-5,6,7,8-tetrahydro-1,8-naphthyridine-2-propionic Acid; 2-[8-[(tert-Butoxy)carbonyl]-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl]propanoic Acid; Boc-Nap-Pro-OH (abbrev.); 886362-45-4; 8-Boc-1,8-naphthyridine-2-propanoic acid derivative
EINECS	Contact for details

Quality Control

Our production of 8-n-Boc-5,6,7,8-Tetrahydro-1,8-Naphthyridin-2-Propoinic Acid adheres to stringent internal quality standards designed for research and pharmaceutical applications. Each batch undergoes comprehensive analytical characterization including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under inert atmosphere for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.