Description

tert-Butyl 1-Oxa-4,8-Diazaspiro[4.5]Decane-8-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing complex molecules with potential therapeutic activity. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new active pharmaceutical ingredients (APIs), particularly in areas like central nervous system (CNS) and oncology drug discovery.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of novel drug candidates, especially those targeting neurological receptors.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Development: Integral in the development and scale-up processes for new Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Probes: Serves as a core structure for designing molecular probes to study biological pathways and protein function.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects requiring complex heterocyclic chemistry.
• Library Synthesis: Used in the generation of diverse compound libraries for high-throughput screening (HTS) campaigns.

Basic Information

Product Name	tert-Butyl 1-Oxa-4,8-Diazaspiro[4.5]Decane-8-Carboxylate
CAS No.	886360-95-8
Molecular Formula	C12H22N2O3
Molecular Weight	242.32 g/mol
Synonyms	8-Boc-1-oxa-4,8-diazaspiro[4.5]decane; 1-Oxa-4,8-diazaspiro[4.5]decane-8-carboxylic acid, 1,1-dimethylethyl ester; tert-Butyl 1-oxa-4,8-diazaspiro[4.5]decane-8-carboxylate; 1-Oxa-4,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester; Boc-1-oxa-4,8-diazaspiro[4.5]decane; 8-(tert-Butoxycarbonyl)-1-oxa-4,8-diazaspiro[4.5]decane
EINECS	Contact for details

Quality Control

Our tert-Butyl 1-Oxa-4,8-Diazaspiro[4.5]Decane-8-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ICH guidelines for stability and impurity characterization, ensuring the material meets the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.