Description

Methyl 5-Chloro-2-Hydroxynicotinate is a high-purity, versatile chemical intermediate with significant value in advanced organic synthesis. Its core utility lies in its functionalized pyridine ring, which serves as a critical building block for constructing complex, nitrogen-containing heterocycles. This compound is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and anti-infectives.
• Agrochemical Synthesis: Building block for developing new herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Ligand and Catalyst Development: Used to create specialized ligands for metal catalysis and organocatalysts in asymmetric synthesis.
• Material Science Research: Intermediate in the production of functionalized polymers and advanced organic electronic materials.
• Chemical Research & Development: A versatile scaffold for medicinal chemistry and process chemistry optimization in laboratory-scale and pilot-plant settings.

Basic Information

Product Name	Methyl 5-Chloro-2-Hydroxynicotinate
CAS No.	886360-77-6
Molecular Formula	C7H6ClNO3
Molecular Weight	187.58 g/mol
Synonyms	5-Chloro-2-hydroxy-nicotinic acid methyl ester; Methyl 5-chloro-2-oxo-1,2-dihydropyridine-3-carboxylate; 5-Chloro-2-hydroxypyridine-3-carboxylic acid methyl ester; 3-Carbomethoxy-5-chloro-2-hydroxypyridine; 886360-77-6; Methyl 5-chloro-2-pyridone-3-carboxylate
EINECS	Contact for details

Quality Control

Our Methyl 5-Chloro-2-Hydroxynicotinate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for GMP-related synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.