Description

(E)-3-[2-(Pyridin-2-Yl)Ethenyl]-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazol-6-Amine is a high-purity, advanced pharmaceutical intermediate characterized by its specific indazole-pyridine hybrid structure. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel, targeted therapeutic agents. It is primarily required by research institutions and pharmaceutical development companies engaged in the discovery of new drug candidates, particularly in oncology and other disease areas.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates, especially kinase inhibitors and other targeted small molecules.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop compounds with improved efficacy and pharmacokinetic profiles.
• Biochemical Probe Development: Employed in the creation of chemical probes for studying specific biological pathways and target validation in cellular assays.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for fundamental research in heterocyclic chemistry and drug discovery methodologies.

Basic Information

Product Name	(E)-3-[2-(Pyridin-2-Yl)Ethenyl]-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazol-6-Amine
CAS No.	886230-76-8
Molecular Formula	C19H20N4O
Molecular Weight	320.39 g/mol
Synonyms	6-Amino-3-[(E)-2-(2-pyridinyl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole; 1-(Oxan-2-yl)-3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-amine; THP-protected Indazole-Pyridine Intermediate; CAS 886230-76-8; (E)-6-Amino-3-(2-(pyridin-2-yl)vinyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
EINECS	Contact for details

Quality Control

Our production of (E)-3-[2-(Pyridin-2-Yl)Ethenyl]-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazol-6-Amine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical R&D. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP guidelines for advanced intermediates and can provide material suitable for use under an appropriate Drug Master File (DMF) or similar regulatory framework.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.