Description

5-(4-Trifluoromethylphenyl)Nicotinic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its distinct trifluoromethylphenyl-substituted pyridinecarboxylic acid structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), where its unique fluorine-containing moiety can significantly enhance metabolic stability and bioavailability. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new therapeutic agents and crop protection solutions.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of new drug candidates, particularly in oncology, neurology, and anti-inflammatory therapeutic areas.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group can improve activity and environmental profile.
• Ligand Synthesis: Serves as a precursor for creating specialized ligands used in catalysis and material science.
• Organic Electronic Materials: Investigated as a component in the synthesis of organic semiconductors and light-emitting materials.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying biological processes and target engagement.

Basic Information

Product Name	5-(4-Trifluoromethylphenyl)Nicotinic Acid
CAS No.	885959-44-4
Molecular Formula	C13H8F3NO2
Molecular Weight	267.21 g/mol
Synonyms	5-[4-(Trifluoromethyl)phenyl]pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 5-[4-(trifluoromethyl)phenyl]-; 5-(4-Trifluoromethyl-phenyl)-nicotinic acid; Nicotinic acid, 5-(4-(trifluoromethyl)phenyl)-; 885959-44-4
EINECS	Contact for details

Quality Control

Our 5-(4-Trifluoromethylphenyl)Nicotinic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.