Description

5-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-2-hexynal is a specialized silyl-protected alkyne aldehyde building block, a key intermediate in advanced organic synthesis. Its value lies in its dual functional groups, which allow for precise and sequential chemical modifications under controlled conditions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, particularly for constructing complex molecular architectures in drug discovery and active ingredient development.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of novel therapeutic agents.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and plant growth regulators requiring specific alkyne and aldehyde functionalities.
• Material Science Research: Serves as a precursor for functionalized polymers and advanced materials with tailored properties.
• Cross-Coupling Reactions: Utilized in Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions to form complex carbon-carbon bonds.
• Natural Product Synthesis: A valuable synthon for the total synthesis of complex natural products with alkyne and aldehyde motifs.
• Ligand and Catalyst Development: Employed in the creation of novel chiral ligands and organocatalysts for asymmetric synthesis.

Basic Information

Product Name	5-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-2-hexynal
CAS No.	885680-12-6
Molecular Formula	C12H22O2Si
Molecular Weight	226.39 g/mol
Synonyms	5-[(tert-Butyldimethylsilyl)oxy]-2-hexynal; 5-(TBDMSO)-2-hexynal; 2-Hexynal, 5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-; 5-(tert-Butyldimethylsiloxy)-2-hexynal; tert-Butyldimethyl(5-oxo-2-hexyn-1-yloxy)silane; TBDMS-protected 5-hydroxy-2-hexynal; 5-O-TBDMS-2-hexynal
EINECS	Contact for details

Quality Control

Our 5-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-2-hexynal is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most sensitive synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.