Description

Methyl 2-Bromo-5-Fluoroisonicotinate is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for introducing halogenated pyridine motifs into target structures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides that require halogenated pyridine cores.
• Material Science Research: Serves as a building block for creating functionalized ligands, organic semiconductors, and advanced polymers.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Negishi cross-coupling reactions to form biaryl and other complex structures.
• Nucleophilic Substitution: The bromine and ester functional groups provide handles for further derivatization via nucleophilic aromatic substitution and ester hydrolysis/transformation.
• Chemical Biology Probes: Used in the design and synthesis of molecular probes for studying biological systems and enzyme mechanisms.

Basic Information

Item	Details
Product Name	Methyl 2-Bromo-5-Fluoroisonicotinate
CAS No.	885588-14-7
Molecular Formula	C7H5BrFNO2
Molecular Weight	234.02 g/mol
Synonyms	Methyl 2-bromo-5-fluoropyridine-4-carboxylate; 2-Bromo-5-fluoro-4-pyridinecarboxylic acid methyl ester; 4-Pyridinecarboxylic acid, 2-bromo-5-fluoro-, methyl ester; Methyl 2-bromo-5-fluoroisonicotinate; 2-Bromo-5-fluoropyridine-4-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 2-Bromo-5-Fluoroisonicotinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We are committed to meeting the stringent requirements of research and development as well as cGMP standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.