Description

1-Boc-4-Cyano-4-(4-Chlorobenzyl)-Piperidine is a high-purity, advanced pharmaceutical intermediate featuring a versatile piperidine scaffold with protective and functional groups. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and receptor-targeted drug discovery programs. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its modifiable Boc-protected amine and cyano groups.
• Process Chemistry Development: Serves as a starting material or intermediate in scaling up synthetic routes for potential APIs under Good Manufacturing Practice (GMP) conditions.
• Library Synthesis: Employed in combinatorial and parallel synthesis to create diverse chemical libraries for high-throughput screening.
• Protease Inhibitor Scaffold: The piperidine core is relevant in the development of protease and enzyme inhibitors.
• Custom Synthesis: Basis for the custom manufacture of more complex, proprietary compounds for client-specific research projects.

Basic Information

Product Name	1-Boc-4-Cyano-4-(4-Chlorobenzyl)-Piperidine
CAS No.	885500-39-0
Molecular Formula	C18H23ClN2O2
Molecular Weight	334.84 g/mol
Synonyms	1-Boc-4-Cyano-4-(4-Chlorobenzyl)piperidine; tert-Butyl 4-cyano-4-[(4-chlorophenyl)methyl]piperidine-1-carboxylate; 4-[(4-Chlorophenyl)methyl]-4-cyano-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester; 4-Cyano-4-(4-chlorobenzyl)piperidine-1-carboxylic Acid tert-Butyl Ester; 1-(tert-Butoxycarbonyl)-4-cyano-4-(4-chlorobenzyl)piperidine; 4-(4-Chlorobenzyl)-4-cyano-1-piperidinecarboxylic Acid tert-Butyl Ester; 1-Boc-4-(4-chlorobenzyl)-4-cyanopiperidine
EINECS	Contact for details

Quality Control

Our 1-Boc-4-Cyano-4-(4-Chlorobenzyl)-Piperidine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes. Our quality commitment supports development from research to commercial scale, adhering to relevant ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.