Description

1-[[2-(Trimethylsilyl)Ethoxy]Methyl]-1H-Pyrazol-3-Amine is a specialized organosilicon-protected pyrazole derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its role as a protected amine intermediate, enabling the construction of complex heterocyclic scaffolds under conditions where a free amine group would be incompatible. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting kinase inhibitors and other heterocyclic-based therapeutics.
• Agrochemical Synthesis: Used in the development of new pesticides and herbicides, where the pyrazole core is a common pharmacophore for biological activity.
• Material Science Research: Serves as a precursor for functionalized polymers or ligands in catalysis due to its silicon-protecting group, which allows for selective deprotection.
• Chemical Biology Probes: Employed in the creation of tagged or modified biomolecules for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing high-value, low-volume specialty chemicals.

Basic Information

Product Name	1-[[2-(Trimethylsilyl)Ethoxy]Methyl]-1H-Pyrazol-3-Amine
CAS No.	885325-91-7
Molecular Formula	C10H23N3OSi
Molecular Weight	229.40 g/mol
Synonyms	1-((2-(Trimethylsilyl)ethoxy)methyl)-1H-pyrazol-3-amine; 1H-Pyrazol-3-amine, 1-[[2-(trimethylsilyl)ethoxy]methyl]-; 1-((2-(Trimethylsilyl)ethoxy)methyl)-3-aminopyrazole; 3-Amino-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole; 1-(2-Trimethylsilylethoxymethyl)-1H-pyrazol-3-ylamine; SEM-protected 3-aminopyrazole; 885325-91-7
EINECS	Contact for details

Quality Control

Our production of 1-[[2-(Trimethylsilyl)Ethoxy]Methyl]-1H-Pyrazol-3-Amine adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and development applications. All materials are fully characterized using advanced analytical techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.