Description

1,8-Diaza-Spiro[4.5]Decane-1-Carboxylic Acid tert-Butyl Ester is a high-purity, protected spirocyclic amine building block of significant value in modern synthetic chemistry. Its rigid, three-dimensional structure is crucial for constructing complex molecular architectures with enhanced biological activity and selectivity. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral scaffold in the research and development of new drug candidates, especially for neurological and psychiatric applications.
• Medicinal Chemistry: Used to introduce a constrained, spirocyclic amine moiety into lead compounds to improve potency, metabolic stability, and receptor selectivity.
• Agrochemical Synthesis: Serves as a sophisticated building block for creating novel pesticides and herbicides with specific modes of action.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes, enzyme inhibitors, and tool compounds for biological target validation.
• Academic & Contract Research: Essential for synthetic methodology development and exploring new chemical space in university and CRO laboratory settings.
• Peptidomimetics: Used to create non-peptide analogs that mimic the structure and function of peptides, enhancing stability and bioavailability.

Basic Information

Product Name	1,8-Diaza-Spiro[4.5]Decane-1-Carboxylic Acid tert-Butyl Ester
CAS No.	885279-92-5
Molecular Formula	C13H24N2O2
Molecular Weight	240.34 g/mol
Synonyms	tert-Butyl 1,8-diaza-spiro[4.5]decane-1-carboxylate; 1,8-Diaza-spiro[4.5]decane-1-carboxylic acid 1,1-dimethylethyl ester; 1-Boc-1,8-diaza-spiro[4.5]decane; 1-N-Boc-1,8-diaza-spiro[4.5]decane; 1,8-Diazaspiro[4.5]decane-1-carboxylic acid tert-butyl ester; Boc-1,8-diaza-spiro[4.5]decane; Spirocyclic Boc-protected amine
EINECS	Contact for details

Quality Control

Our 1,8-Diaza-Spiro[4.5]Decane-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and scale-up applications. We provide comprehensive analytical data, including HPLC purity, chiral purity (where applicable), and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing all specifications are available for every batch and provided upon request to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.