Description

5-Trifluoromethoxy-Benzo[B]Thiophene-2-Carboxylic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate and versatile organic building block. This compound is valued for its unique molecular architecture, which incorporates both a benzo[b]thiophene core and a trifluoromethoxy substituent, enabling precise modifications in complex synthesis. It is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and material science industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Synthesis: Used as a building block for creating novel herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science Research: Serves as a precursor for organic electronic materials, such as semiconductors and light-emitting materials, due to its fused aromatic system.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for catalysis and molecular recognition applications.
• Fluorine Chemistry Studies: Acts as a model compound for investigating the effects of the trifluoromethoxy group on reactivity and physicochemical properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and small-scale commercial batches.

Basic Information

Product Name	5-Trifluoromethoxy-Benzo[B]Thiophene-2-Carboxylic Acid Methyl Ester
CAS No.	885279-16-3
Molecular Formula	C11H7F3O3S
Molecular Weight	276.23 g/mol
Synonyms	Methyl 5-(Trifluoromethoxy)-1-benzothiophene-2-carboxylate; 5-(Trifluoromethoxy)benzo[b]thiophene-2-carboxylic acid methyl ester; 1-Benzothiophene-2-carboxylic acid, 5-(trifluoromethoxy)-, methyl ester; Methyl 5-trifluoromethoxybenzo[b]thiophene-2-carboxylate; 885279-16-3; 5-Trifluoromethoxybenzo[b]thiophene-2-methyl carboxylate
EINECS	Contact for details

Quality Control

Every batch of 5-Trifluoromethoxy-Benzo[B]Thiophene-2-Carboxylic Acid Methyl Ester is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing all critical quality attributes are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.