Description

5-Trifluoromethoxy-Benzo[B]Thiophene-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique heterocyclic structure containing both a benzo[b]thiophene core and a trifluoromethoxy substituent. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating compounds with potential enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in oncology, CNS, and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group can improve lipophilicity and biological activity.
• Material Science Research: Serves as a precursor for the development of organic electronic materials, such as semiconductors or light-emitting materials.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel ligands for catalysis.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	5-Trifluoromethoxy-Benzo[B]Thiophene-2-Carboxylic Acid
CAS No.	885279-13-0
Molecular Formula	C10H5F3O3S
Molecular Weight	262.21 g/mol
Synonyms	5-(Trifluoromethoxy)-1-benzothiophene-2-carboxylic acid; 5-(Trifluoromethoxy)benzo[b]thiophene-2-carboxylic acid; 2-Carboxy-5-trifluoromethoxybenzo[b]thiophene; 885279-13-0; 5-Trifluoromethoxybenzothiophene-2-carboxylic Acid
EINECS	Contact for details

Quality Control

Our production of 5-Trifluoromethoxy-Benzo[B]Thiophene-2-Carboxylic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your internal specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and organic solvents. The container must be kept tightly closed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.