Description

1-(4-Chloro-Pyridin-2-Yl)-Piperazine CAS NO 885277-30-5 is a high-purity, heterocyclic organic compound featuring a piperazine ring linked to a chloropyridine moiety. This specific molecular architecture makes it a critical building block (synthon) for pharmaceutical research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in creating new therapeutic agents, especially within the domains of central nervous system (CNS) and anti-infective drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• CNS Drug Development: Used in the research of potential therapeutics targeting neurological disorders, leveraging the piperazine pharmacophore.
• Anti-infective Agent Synthesis: Employed in the development pathway for novel antibacterial or antifungal compounds.
• Ligand for Catalysis: Can be utilized to create specialized ligands for metal-catalyzed reactions in fine chemical synthesis.
• Agrochemical Research: Potential intermediate in the development of new pesticides or herbicides.

Basic Information

Product Name	1-(4-Chloro-Pyridin-2-Yl)-Piperazine
CAS No.	885277-30-5
Molecular Formula	C9H12ClN3
Molecular Weight	197.66 g/mol
Synonyms	1-(4-Chloropyridin-2-yl)piperazine; 2-(4-Chloropyridin-2-yl)piperazine; 4-Chloro-2-piperazin-1-ylpyridine; 1-(4-Chloro-2-pyridinyl)piperazine; 885277-30-5; 4-Chloro-2-(piperazin-1-yl)pyridine; 2-Piperazin-1-yl-4-chloropyridine
EINECS	Contact for details

Quality Control

Our 1-(4-Chloro-Pyridin-2-Yl)-Piperazine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.