Description

5-tert-Butoxycarbonylamino-2-Chloro-Nicotinic Acid is a high-purity, protected amino acid derivative and a versatile chemical building block. This compound is critical for the synthesis of complex molecules, offering a reactive scaffold for constructing pharmacologically active structures. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs) and fine chemical intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting nicotinic acid derivatives.
• Peptide Mimetics & Conjugate Synthesis: Serves as a protected amino acid component for constructing peptide-like structures and bioconjugates.
• Agrochemical Research: Used in the research and development of advanced crop protection agents and herbicides.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis services catering to the fine chemical and life science industries.
• Academic & Industrial R&D: A valuable reagent for exploratory chemistry in academic laboratories and corporate R&D centers focused on heterocyclic chemistry.

Basic Information

Product Name	5-tert-Butoxycarbonylamino-2-Chloro-Nicotinic Acid
CAS No.	885277-14-5
Molecular Formula	C11H13ClN2O4
Molecular Weight	272.69 g/mol
Synonyms	2-Chloro-5-[(tert-butoxycarbonyl)amino]nicotinic acid; 5-[(tert-Butoxycarbonyl)amino]-2-chloropyridine-3-carboxylic acid; Boc-5-Amino-2-chloronicotinic Acid; 5-(Boc-amino)-2-chloronicotinic acid; 2-Chloro-5-((tert-butoxycarbonyl)amino)nicotinic acid; 5-(tert-Butoxycarbonylamino)-2-chloronicotinic acid; 2-Chloro-5-[(tert-butoxycarbonyl)amino]-3-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 5-tert-Butoxycarbonylamino-2-Chloro-Nicotinic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.