Description

2-Chloro-4-(2,2,2-trifluoro-ethoxy)-pyridine is a high-purity fluorinated pyridine derivative, a crucial building block in advanced organic synthesis. Its unique structure, featuring both a chloro and a trifluoroethoxy substituent, makes it an essential intermediate for creating complex molecules with tailored properties. This compound is primarily sought by R&D and production teams in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) and metabolic diseases.
• Agrochemical Synthesis: Serves as a critical precursor in the manufacture of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Used in the design of specialized ligands for transition metal catalysis, enabling more efficient and selective chemical transformations.
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic electronic materials due to its electron-withdrawing characteristics.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Chloro-4-(2,2,2-trifluoro-ethoxy)-pyridine
CAS No.	885277-01-0
Molecular Formula	C7H5ClF3NO
Molecular Weight	211.57 g/mol
Synonyms	2-Chloro-4-(2,2,2-trifluoroethoxy)pyridine; 4-(2,2,2-Trifluoroethoxy)-2-chloropyridine; Pyridine, 2-chloro-4-(2,2,2-trifluoroethoxy)-; 2-Chloro-4-(trifluoroethoxy)pyridine; 885277-01-0; 2-Chloro-4-(2,2,2-trifluoroethyloxy)pyridine
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-4-(2,2,2-trifluoro-ethoxy)-pyridine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.