Description

(3-Boc-Amino-Azetidin-1-Yl)-p-Tolyl-Acetic Acid is a high-value, protected amino acid derivative featuring a Boc-protected azetidine ring linked to a p-tolylacetic acid moiety. This compound serves as a critical chiral building block and advanced pharmaceutical intermediate in modern organic synthesis. It is primarily utilized by research institutions and pharmaceutical manufacturers for the development of novel active pharmaceutical ingredients (APIs), particularly in protease inhibitor and other small-molecule drug discovery programs.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of complex drug candidates, especially protease inhibitors and other biologically active molecules.
• Peptidomimetics Research: Used in the design and construction of peptidomimetic scaffolds due to its constrained azetidine ring structure, which can improve metabolic stability and bioavailability.
• Medicinal Chemistry: Serves as a versatile building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery projects.
• Custom Synthesis: Employed in contract research and manufacturing organizations (CROs/CMOs) for the custom synthesis of proprietary compounds and reference standards.
• Chemical Biology: Can be utilized as a tool compound or a linker in the development of chemical probes for studying biological pathways.

Basic Information

Product Name	(3-Boc-Amino-Azetidin-1-Yl)-p-Tolyl-Acetic Acid
CAS No.	885275-90-1
Molecular Formula	C₁₇H₂₄N₂O₄
Molecular Weight	320.38 g/mol
Synonyms	1-[(4-Methylphenyl)acetyl]-3-[[(1,1-dimethylethoxy)carbonyl]amino]azetidine; 3-[(tert-Butoxycarbonyl)amino]-1-[(4-methylphenyl)acetyl]azetidine; (3-{[(tert-Butoxycarbonyl)amino]}-1-azetidinyl)(4-methylphenyl)acetic acid; (3-Boc-amino-1-azetidinyl)(p-tolyl)acetic acid; (3-Boc-Amino-azetidin-1-yl)-p-tolyl-acetic acid; BOC-Azetidine-p-Tolylacetic Acid Derivative; tert-Butyl N-[1-[(4-methylphenyl)acetyl]azetidin-3-yl]carbamate
EINECS	Contact for details

Quality Control

Our (3-Boc-Amino-Azetidin-1-Yl)-p-Tolyl-Acetic Acid is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support pre-clinical and clinical-stage pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.