Description

1-Boc-4-Chloro-5-Formyl-3,6-Dihydro-2H-Pyridine is a high-value, multi-functional chemical intermediate characterized by its protected amine (Boc) and reactive aldehyde and chloro substituents. This compound matters for its critical role in the synthesis of complex nitrogen-containing heterocycles, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel piperidine-based scaffolds and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of piperidine and piperazine derivatives, which are core structures in numerous therapeutic agents targeting the central nervous system, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used in high-throughput screening and combinatorial chemistry for the discovery and optimization of new drug candidates due to its versatile reactive sites for further functionalization.
• Agrochemical Synthesis: Intermediate in the production of advanced crop protection agents and pesticides that require complex heterocyclic frameworks.
• Chemical Biology Probes: Serves as a precursor for creating labeled compounds or molecular probes used in biochemical and pharmacological studies.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for the bespoke production of client-specific advanced intermediates under cGMP conditions.
• Academic Research: Utilized in university and institutional laboratories for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Item	Detail
Product Name	1-Boc-4-Chloro-5-Formyl-3,6-Dihydro-2H-Pyridine
CAS No.	885275-20-7
Molecular Formula	C11H16ClNO3
Molecular Weight	245.70 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-4-chloro-5-formyl-3,6-dihydro-2H-pyridine; 4-Chloro-5-formyl-1-Boc-1,2,3,6-tetrahydropyridine; tert-Butyl 4-chloro-5-formyl-3,6-dihydro-2H-pyridine-1-carboxylate; 1-Boc-4-chloro-5-formyl-1,2,3,6-tetrahydropyridine; Boc-4-Cl-5-CHO-3,6-dihydro-2H-pyridine; N-Boc-4-chloro-5-formyl-3,6-dihydro-2H-pyridine; 4-Chloro-5-formyl-N-Boc-3,6-dihydro-2H-pyridine
EINECS	Contact for details

Quality Control

Our 1-Boc-4-Chloro-5-Formyl-3,6-Dihydro-2H-Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects requiring compliance with ICH guidelines and can supply material suitable for use in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.