Description

2-Bromo-1H-Pyrrolo[2,3-C]Pyridine is a versatile brominated heterocyclic building block of significant interest in advanced organic synthesis. Its core pyrrolopyridine scaffold, functionalized with a reactive bromine atom, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its modifiable bromine site.
• Agrochemical Development: Employed in the research and synthesis of novel crop protection agents and herbicides.
• Material Science Precursor: Acts as a building block for creating organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination cross-coupling reactions to form new carbon-carbon and carbon-heteroatom bonds.
• Chemical Biology Probes: Utilized in the development of molecular probes and tags for studying biological systems and pathways.

Basic Information

Product Name	2-Bromo-1H-Pyrrolo[2,3-C]Pyridine
CAS No.	885272-38-8
Molecular Formula	C7H5BrN2
Molecular Weight	197.04 g/mol
Synonyms	2-Bromo-1H-pyrrolo[2,3-c]pyridine; 2-Bromo-7-azaindole; 2-Bromo-1H-pyrrolo[2,3-c]pyridine; 1H-Pyrrolo[2,3-c]pyridine, 2-bromo-; 2-Bromo-7-aza-indole; 2-Bromo-1H-7-azaindole; 2-Bromopyrrolo[2,3-c]pyridine
EINECS	Contact for details

Quality Control

Our 2-Bromo-1H-Pyrrolo[2,3-C]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.