Description

Octahydro-Pyrrolo[3,4-C]Pyridine-2-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its fused bicyclic structure. This compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. It is essential for research and development chemists and production teams in the pharmaceutical and fine chemical industries who require reliable, high-quality intermediates for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug molecules, especially for neurological and psychiatric disorders.
• API Synthesis: Used as a core scaffold or precursor in the production of Active Pharmaceutical Ingredients (APIs) requiring a rigid, nitrogen-containing bicyclic framework.
• Medicinal Chemistry R&D: Serves as a versatile building block for constructing novel chemical libraries in drug discovery programs focused on GPCR targets and enzyme inhibitors.
• Asymmetric Synthesis: Employed in stereoselective synthesis due to its defined stereochemistry, enabling the production of enantiomerically pure compounds.
• Fine Chemical Production: Utilized in the manufacture of specialty chemicals and complex organic molecules for agrochemical and material science applications.

Basic Information

Product Name	Octahydro-Pyrrolo[3,4-C]Pyridine-2-Carboxylic Acid tert-Butyl Ester
CAS No.	885270-57-5
Molecular Formula	C12H21NO2
Molecular Weight	211.30 g/mol
Synonyms	tert-Butyl octahydro-1H-pyrrolo[3,4-c]pyridine-2-carboxylate; 1H-Pyrrolo[3,4-c]pyridine-2-carboxylic acid, octahydro-, 1,1-dimethylethyl ester; (3aR,7aR)-tert-Butyl hexahydro-1H-pyrrolo[3,4-c]pyridine-2(3H)-carboxylate; (3aR,7aR)-tert-Butyl octahydro-1H-pyrrolo[3,4-c]pyridine-2-carboxylate; Bicyclic Proline Derivative tert-Butyl Ester; tert-Butyl (3aR,7aR)-octahydro-1H-pyrrolo[3,4-c]pyridine-2-carboxylate
EINECS	Contact for details

Quality Control

Our Octahydro-Pyrrolo[3,4-C]Pyridine-2-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and chiral purity analysis, to ensure it meets the stringent requirements for pharmaceutical intermediate use. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.