Description

8'-Bromo-2',3'-dihydro-1'H-spiro[cyclopentane-1,4'-isoquinoline] CAS NO 885269-41-0 is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic molecular architecture. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for synthesizing novel bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in central nervous system (CNS) and oncology drug discovery programs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, especially those targeting neurological receptors.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery projects.
• Ligand Synthesis: Employed in the preparation of specialized ligands for biological target validation and assay development.
• Chemical Biology Probes: Serves as a core structure for creating molecular probes to study enzyme function and protein interactions.
• Academic Research: Utilized in university and institutional laboratories for fundamental studies in organic synthesis and heterocyclic chemistry.
• Contract Research Organizations (CROs): Supplied to CROs engaged in custom synthesis and early-stage drug development for clients.

Basic Information

Product Name	8'-Bromo-2',3'-dihydro-1'H-spiro[cyclopentane-1,4'-isoquinoline]
CAS No.	885269-41-0
Molecular Formula	C₁₃H₁₄BrN
Molecular Weight	264.16 g/mol
Synonyms	8'-Bromospiro[cyclopentane-1,4'-isoquinoline]; 8'-Bromo-1'H-spiro[cyclopentane-1,4'-isoquinoline]; 8-Bromo-2,3-dihydro-1H-spiro[cyclopentane-1,4'-isoquinoline]; 885269-41-0; Spiro[cyclopentane-1,4'-isoquinoline], 8'-bromo-2',3'-dihydro-; 8'-Bromo-2',3'-dihydrospiro[cyclopentane-1,4'-isoquinoline]; 8'-Bromo-1',2',3',4'-tetrahydrospiro[cyclopentane-1,1'-isoquinoline]
EINECS	Contact for details

Quality Control

Our 8'-Bromo-2',3'-dihydro-1'H-spiro[cyclopentane-1,4'-isoquinoline] is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the stringent requirements of pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.